馬文只呈現證據!!!
於醫藥,醫美產品臨床研究 歐洲與美國是領先於台灣。馬文呈現最新全球的法律規定,提供給我們社團朋友們暸解!!

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美國加州大學柏克萊分校的研究人員在美國《環境狀況觀察》月刊發表論文

對於Paraben 類之防腐劑,馬文將找尋最新之醫學期刊,來向大家說明,提供予親愛的馬友們可以參考!

這一篇文獻的重點整理:

1. Parabens(對羥基苯甲酸酯)是使用最廣泛的外源性雌激素在化妝品和個人護理產品中。
2. 外源性雌激素(Xenoestrogen),會對任何生物有生殖方面的影響,使得幼體發育延遲。
3. 這一篇研究是來看看parabens( 對羥基苯甲酸酯)是否會增加與人表皮生長因子受體(HER)結合,而增加 heregulin(HRG)生長因子的活性。Heregulin(HRG)則是乳癌細胞促長劑
4. 研究表示,在人體外的實驗中,研究結果Butylparaben (BP)在低劑量1% 也會增加刺激人表皮生長因子受體(HER)通過estrogen receptor (ERα) 雌激素受體而提高癌基因與乳腺癌細胞增殖。

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雖然台灣保養品法規上沒有禁止使用,但確實應該將Paraben類防腐劑添加物的使用,納入您的考慮。

ENVIRONMENTAL
HEALTH
PERSPECTIVES
Parabens and Human Epidermal Growth Factor
Receptor Ligands Cross-Talk in Breast Cancer Cells
Shawn Pan, Chaoshen Yuan, Abderrahmane Tagmount,
Ruthann A. Rudel, Janet M. Ackerman, Paul Yaswen,
Chris D. Vulpe, and Dale C. Leitman

Received: 10 September 2014
Accepted: 9 October 2015
Advance Publication: 27 October 2015

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原文摘要如下:
Abstract
BACKGROUND:
Xenoestrogens are synthetic compounds that mimic endogenous estrogens by binding to and activating estrogen receptors. Exposure to estrogens and some xenoestrogens has been associated with cell proliferation and increased risk of breast cancer. Despite evidence of estrogenicity, parabens are among the most widely used xenoestrogens in cosmetics and personal care products, and generally considered safe. However, previous cell based studies with parabens do not take into account the signaling cross-talk between estrogen receptor (ERα) and the human epidermal growth factor receptor (HER) family.

OBJECTIVES:
We investigated the hypothesis that the potency of parabens can be increased with HER ligands, such as heregulin (HRG).

METHODS:
The effects of HER ligands on paraben activation of c-Myc expression and cell proliferation were determined by real-time PCR, western blots, flow cytometry and chromatin immunoprecipitation assays in ERα- and HER2-positive human BT-474 breast cancer cells.

RESULTS:
Butylparaben (BP) and HRG produced a synergistic increase in c-Myc mRNA and protein levels in BT-474 cells. Estrogen receptor antagonists blocked the synergistic increase in c-Myc protein levels. The combination of BP and HRG also stimulated proliferation of BT-474 cells compared to BP alone. HRG decreased the dose required for BP-mediated stimulation of c-Myc mRNA expression and cell proliferation. HRG caused the phosphorylation of serine 167 in ERα. BP and HRG produced a synergistic increase in ERα recruitment to the c-Myc gene.

CONCLUSION:
Our studies demonstrate that HER ligands enhance the potency of BP to stimulate oncogene expression and breast cancer cell proliferation in vitro via ERα, suggesting that parabens might be active at exposure levels not previously considered toxicologically relevant from studies testing their effects in isolation.